Advances in anatomical knowledge of the body’s connective tissue is making waves through treatments offered by manual therapists. The understanding of trigger points, myofascial pain syndromes, pain referral patterns and electrical activity in the tissues has created a huge toolbox of techniques for practitioners. A good practitioner has the ability to choose appropriate techniques at the right time for their patients, as well as an understanding of when to refer on to specialists in other areas. A multifaceted approach has the best outcome by far.